Cart
sales@molnova.com
Autotaxin inhibitor 12
CAS No. 1613513-14-6
Autotaxin inhibitor 12( —— )
Catalog No. M12344 CAS No. 1613513-14-6
Autotaxin inhibitor 12 is a highly potent, selective, orally-bioavailable inhibitor of autotaxin with IC50 of 3.1 nM in choline release assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAutotaxin inhibitor 12
-
NoteResearch use only, not for human use.
-
Brief DescriptionAutotaxin inhibitor 12 is a highly potent, selective, orally-bioavailable inhibitor of autotaxin with IC50 of 3.1 nM in choline release assays.
-
DescriptionAutotaxin inhibitor 12 is a highly potent, selective, orally-bioavailable inhibitor of autotaxin with IC50 of 3.1 nM in choline release assays; shows ATX inhibition of IC50 9 nM in an in vitro serum assay, measuring 18:1 LPA levels by LCMS; concentration-dependently inhibits autotaxin and formation of LPA in vivo.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayWnt/Notch/Hedgehog
-
TargetAutotaxin
-
RecptorAutotaxin
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1613513-14-6
-
Formula Weight440.325
-
Molecular FormulaC19H23Cl2N5O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC1CN(CCC1NC(=O)CCCC2=NNN=C2)C(=O)OCC3=CC(=CC(=C3)Cl)Cl
-
Chemical Name3,5-dichlorobenzyl 4-(4-(1H-1,2,3-triazol-4-yl)butanamido)piperidine-1-carboxylate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Thomson CG, et al. Bioorg Med Chem Lett. 2018 May 21. pii: S0960-894X(18)30431-1.
molnova catalog
related products
-
BI-2545
BI-2545 is a novel potent, selective, orally available Autotaxin inhibitor with IC50 of 2.1 and 3.4 nM for huamn and rat ATX, respectively.
-
GWJ-A-23
GWJ-A-23 (GWJ-23, GWJ23) is a?potent, selective autotaxin inhibitor with Ki of 18 nM.
-
Autotaxin inhibitor ...
Autotaxin inhibitor compound 1 (Autotaxin-IN-1) is a potent, selective, orally bioavailable inhibitor of autotaxin with IC50 of 2.2 nM in ex vivo human whole blood assay.
