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Autotaxin inhibitor 12
CAS No. 1613513-14-6
Autotaxin inhibitor 12 ( —— )
Catalog No. M12344 CAS No. 1613513-14-6
Autotaxin inhibitor 12 is a highly potent, selective, orally-bioavailable inhibitor of autotaxin with IC50 of 3.1 nM in choline release assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameAutotaxin inhibitor 12
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NoteResearch use only, not for human use.
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Brief DescriptionAutotaxin inhibitor 12 is a highly potent, selective, orally-bioavailable inhibitor of autotaxin with IC50 of 3.1 nM in choline release assays.
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DescriptionAutotaxin inhibitor 12 is a highly potent, selective, orally-bioavailable inhibitor of autotaxin with IC50 of 3.1 nM in choline release assays; shows ATX inhibition of IC50 9 nM in an in vitro serum assay, measuring 18:1 LPA levels by LCMS; concentration-dependently inhibits autotaxin and formation of LPA in vivo.
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Synonyms——
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PathwayWnt/Notch/Hedgehog
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TargetAutotaxin
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RecptorAutotaxin
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Research Area——
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Indication——
Chemical Information
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CAS Number1613513-14-6
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Formula Weight440.33
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Molecular FormulaC19H23Cl2N5O3
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CN(CCC1NC(=O)CCCC2=NNN=C2)C(=O)OCC3=CC(=CC(=C3)Cl)Cl
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Chemical Name3,5-dichlorobenzyl 4-(4-(1H-1,2,3-triazol-4-yl)butanamido)piperidine-1-carboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Thomson CG, et al. Bioorg Med Chem Lett. 2018 May 21. pii: S0960-894X(18)30431-1.
molnova catalog
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